Hot sale S4 (Andarine) 99.9% high-purity powder is used to increase muscle and reduce fat CAS401900-40-1

Short Description:

Name: S4

CAS No: 401900-40-1

Molecular Formula: C19H18F3N3O6

Molecular Weight: 441.36

EINECS No: 803-892-7

Melting point: 70-74 ℃

Boiling point: 698.7 ± 55.0 ° C (Predicted)

Density: 1.47

Storage conditions: Refrigerator

Solubility: DMSO (Slightly), MetaChemicalbookol (Slightly)

Form: none

Acidity coefficient (pKa): 12.13 ± 0.29 (Predicted)

Color: LightYellow

Water solubility: 1.2mg/mLinwater

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S4 Introduction

S4 is a powerful tool for building lean muscle mass and reducing fat tissue development, but you will be surprised at its development.
S4 is a regulatory factor, which binds with androgen receptor and causes structural changes of androgen receptor.
There are three types of chemicals that react to androgen receptor (AR). There are antagonists, agonists and modulators. Agonists are the types of chemicals attached to androgen receptors, while antagonists have the functions of attachment, separation and reattachment to AR. A regulator is different from androgen receptor, but it changes the structure of androgen receptor, which is what S4 does. Because the structure of androgen receptor has changed now, it will also change its function. This means that when S4 binds to androgen receptor and androgen receptor interacts with testosterone, S4 chemicals force androgen receptor to send signals that only stimulate bone and muscle growth. Without S4, when androgen receptor interacts with testosterone, it will stimulate all effects triggered by testosterone, including good and bad effects. S4 is selective, which means it will try to stimulate the good effect of testosterone.

Effect

The advantage of S4 is that it can stimulate the growth of bones and muscles, but it will not stimulate the growth of secondary sexual organs such as prostate. S4 does not interfere with HDL/LDL ratio, also known as good cholesterol/bad cholesterol ratio. This means that S4 will not pose any threat to the cardiovascular system. S4 is very selective in stimulating muscle and bone growth. It will not cause heart expansion or damage to adjacent organs. More importantly, S4 does not inhibit the testosterone level, which means that it is a women-friendly product and does not need to use PCT.
S4 is not a perfect SARM, which means it has some side effects. One of the most common disadvantages of S4 is that its effect is affected by the law of diminishing returns. This means that there are certain restrictions. As you increase the dose, your return will decrease. Some users reported that S4 has caused a yellow hue to their vision (the dose of more than 50mg per day has a certain probability of occurrence, and the color turns yellow when the light is insufficient). Remember, this is not a permanent side effect. Once you stop taking S4, this side effect will disappear within a few days as S4 leaves the body.

How long will the effect occur

The effect of S4 is relatively fast. When diet and physical activity are suitable, you will notice the first result after using it for a week.

Usage and dosage

It is used to reduce fat, about 50mg per day, for shaping, 50-75mg per day, and for users to increase muscle, more than 75mg per day. Because of its short half-life, it is recommended to supplement it every 4-6 hours.

The service life is 30-60 days.

1. S4 has a low masculinity index, so the possibility of acne, hair loss and greasy is not high
2. The typical second-generation SARM has a small amount of fat control effect while increasing muscle, but it cannot directly help reduce fat
3. The half-life is very short, and it must be taken separately for many times. Those S4 that only take 1-2 times a day are not high-purity or safe products
4. It has obvious side effects: leading to obvious visual impairment, inhibiting testosterone secretion and reducing sperm vitality, which is definitely not the type of SARM recommended by us.

Biological activity

Andrine is a selective non-steroidal androgen receptor (AR) agonist, Ki is 4 nM, and has tissue selectivity for anabolic organs. Phase 3.

In vitro study

In vitro, Andrine binds to androgen receptor with high affinity and Ki is 4 nM. Moreover, 10 nM Andrine stimulated the transcription regulated by androgen receptor, reaching 93%.

In vivo, Andrine has effective anabolic activity, and stimulates the growth of prostate, seminal vesicle, and levator ani muscle. The ED50 is 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day, respectively. This effect is dose-dependent. In addition, Andarine acts on FSH and has no effect on some physiological changes caused by castration, and treatment with 0.5 mg or higher dose per day can partially inhibit LH production. Andarine was administered intravenously to dogs at doses of 0.1, 1, 3, and 10 mg/kg. The total body clearance (CL) decreased from 7.4 mL/min/kg to 3.1 mL/min/kg, the steady-state distribution volume (Vss) was 1.39 L/kg, and the half-life was 229 minutes. In addition, the oral bioavailability of Andarine at 10 mg/kg, 1 mg/kg and 0.1 mg/kg was 38%, 62% and 91% respectively. Andarine has tissue-selective pharmacological activity, and the prostate weight of intact rats was significantly reduced to 79.4% when treated with 0.5 mg/day concentration.

Features

Andrine is a non-steroidal androgen receptor (AR) selective stimulant.

Test Item	Analysis Specification	Result
Description	crystalline powder	Conforms
Melting range	129°C~132°C	130.8°C-131°C
Loss on drying	≤0.5%	0.20 %
Specific rotation	-58°~-62°(C=1,in CH3OH)	-61.05°
Sulphated ash	≤0.1%	0.08 %
Heavy metals	≤10ppm	Conforms
Chlorides	≤0.02%	Conforms
Sulfates	≤0.02%	Conforms
Fluorine	14.7%~17.9%	15.2%
Residual solvent	Methanol ≤0.2% Isopropanol ≤0.2% Ethyl acetate≤0.2% Chloroform ≤0.2%	0.0%
Related substances (HPLC)	Single impurity ≤0.2% Total impurities ≤0.5%	0.05% 0.08%
Assay	≥99.5%	99.9%
Conclusion	Accordance with the reference

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